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The enema tube and solution may stimulate the vagus nerve, which may trigger an arrhythmia such as bradycardia.
Enemas should not be used if there is an undiagnosed abdominal pain since the peristalsis of the bowel can cause an inflamed appendix to rupture.
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In a lower gastrointestinal series an enema that may contain barium sulfate powder or a water-soluble contrast agent is used in the radiological imaging of the bowel.
Called a barium enema, such enemas are sometimes the only practical way to view the colon in a relatively safe manner.